1:05 EDT

	BOS	38-34
Pit: Christopher Johnson 1-0 ERA: 12.706
	BAL	21-49
Pit: John Means 6-4 ERA: 2.604

1:10 EDT

	STL	35-34
Pit: Dakota Hudson 5-3 ERA: 3.468
	NYM	34-36
Pit: Jason Vargas 3-3 ERA: 3.682

1:10 EDT

	TEX	38-32
Pit: Ariel Jurado 4-2 ERA: 3.024
	CIN	30-38
Pit: Sonny Gray 2-5 ERA: 3.645

1:10 EDT

	PIT	31-39
Pit: Christopher Archer 3-6 ERA: 5.732
	MIA	25-43
Pit: Sandy Alcantara 3-6 ERA: 3.671

1:10 EDT

	LAA	35-36
Pit: Griffin Canning 2-2 ERA: 3.654
	TB	42-28
Pit: Ryne Stanek 0-1 ERA: 2.538

1:10 EDT

	CLE	36-33
Pit: Trevor Bauer 4-6 ERA: 3.715
	DET	25-42
Pit: Spencer Turnbull 3-5 ERA: 2.781

1:20 EDT

	PHI	39-31
Pit: Cole Irvin 2-1 ERA: 5.484
	ATL	41-30
Pit: Michael Foltynewicz 1-5 ERA: 6.02

1:35 EDT

	ARI	38-34
Pit: Archie Bradley 2-3 ERA: 4.263
	WSH	32-38
Pit: Aníbal Sánchez 2-6 ERA: 3.922

2:10 EDT

	KC	22-48
Pit: Jakob Junis 4-6 ERA: 5.354
	MIN	47-22
Pit: Martín Pérez 7-2 ERA: 3.967

2:10 EDT

	NYY	42-27
Pit: James Paxton 3-3 ERA: 4.041
	CWS	34-35
Pit: Odrisamer Despaigne 0-1 ERA: 4.5

2:10 EDT

	TOR	25-45
Pit: Trent Thornton 1-5 ERA: 4.78
	HOU	48-23
Pit: Bradley Peacock 6-3 ERA: 3.423

3:10 EDT

	SD	34-37
Pit: Nicholas Margevicius 2-6 ERA: 5.019
	COL	37-33
Pit: Peter Lambert 2-0 ERA: 1.5

4:05 EDT

	MIL	39-31
Pit: Robert Anderson 3-1 ERA: 3.797
	SF	30-38
Pit: Jeffrey Samardzija 3-5 ERA: 3.724

4:07 EDT

	SEA	30-44
Pit: Michael Leake 5-6 ERA: 4.263
	OAK	36-35
Pit: Tanner Anderson 0-1 ERA: 3.176

7:05 EDT

	CHC	39-31
Pit: José Quintana 4-6 ERA: 3.89
	LAD	47-24
Pit: Hyun-Jin Ryu 9-1 ERA: 1.36